Di-isopropylamine Dichloroacetate

Di-isopropylamine Dichloroacetate is a compound in Synthergine™ that may specifically reduce the potential for hepatic injury in the form of fibrosis and cell death. Cell death or necrosis is the final result of obstruction of blood supply following an ongoing incursion of fat infiltrating the liver. This section is devoted to a curing compound Di-isopropylamine Dichloroacetate.

Di-isopropylamine Dichloroacetate is a compound that can be used to reverse fatty acid liver disease.

In 2005 a clinical study ¹ set out to investigate the effectiveness and safety of diisopropylamine dichloroacetate in the treatment of nonalcoholic fatty liver diseases. One hundred twenty three patients who had this disease were randomly assigned to 2 groups treated with either a high dosage (120 mg/d) or a low dosage (60 mg/d) of diisopropylamine dichloroacetate for 8 weeks.

At the end of the 8 week treatment period, the overall improvement of clinical symptoms in the high dosage and in the low dosage group was 87.8% and 79.6%, respectively. These symptoms included fatigue, pain in the upper right abdomen and weight loss ¹.

An alanine aminotransferase (ALT) test measures the amount of this enzyme in the blood and is used to determine if the liver is damaged or diseased. Low levels of ALT are normally found in the blood. But when the liver is damaged or diseased, it releases ALT into the bloodstream, which makes ALT levels go up. Most increases in ALT levels are caused by liver damage ¹.

The study found that ALT which was initially high normalized in 55.7% and 69.4% of the cases in the two groups as a result of Di-isopropylamine Dichloroacetate treatment. Serum lipids, primarily LDL (low-density lipoprotein) and Triglycerides were lowered in 67.2% and 67.7% of the cases in the two groups. Ultrasound grading of the level of liver alteration severity was measured and found to be lowered in 51.7% and 43.5% in the two groups ¹.

The differences found between the two groups were of no statistical significance so the lower dose was sufficient to achieve the positive effects. No severe adverse drug reactions were found ¹.

The study concluded that “Diisopropylamine dichloroacetate could be used as a safe and effective drug in the treatment of nonalcoholic fatty liver diseases ¹.”

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